What dosage of fentanyl is considered lethal?

Fentanyl is an extremely potent synthetic opioid, and its lethality can depend on various factors, including the individual’s tolerance to opioids and their overall health. A dosage of 2 mg of fentanyl is often cited as a lethal dose for non-opioid tolerant individuals. Fentanyl is about 50 to 100 times more potent than morphine, which contributes to its higher risk of overdose.

For most people, especially those without a tolerance to opioids, even small amounts can be dangerous. Therefore, a dosage around 2 mg is widely recognized in medical literature and by authorities as being within the range that can result in respiratory depression and potential death in those not accustomed to opioid use. This makes it crucial to administer fentanyl with extreme caution, especially in settings where patient opioid tolerance is unknown.

The other options represent lower dosages that, while still potentially harmful, are less likely to be lethal for most individuals, particularly those who may already be using opioids under medical supervision. Thus, the identification of 2 mg as a lethal dose underscores the importance of understanding dosage and individual variability in response to powerful opioids like fentanyl.